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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PTK2 All Species: 36.06
Human Site: S443 Identified Species: 79.33
UniProt: Q05397 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q05397 NP_005598.3 1052 119233 S443 V H Q G I Y M S P E N P A L A
Chimpanzee Pan troglodytes XP_001147699 1096 124125 S487 V H Q G I Y M S P E N P A L A
Rhesus Macaque Macaca mulatta XP_001093060 1097 123900 S487 V H Q G V Y M S P E N P A L A
Dog Lupus familis XP_856301 1068 120990 S456 V H Q G V Y M S P E N P A L A
Cat Felis silvestris
Mouse Mus musculus P34152 1090 123518 S481 V H Q G V Y L S P E N P A L A
Rat Rattus norvegicus O35346 1055 119698 S443 V H Q G V Y L S P E N P A L A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510393 1059 119735 T443 V H Q G V Y T T P E N P A M A
Chicken Gallus gallus Q00944 1053 119189 S443 V H Q G I Y M S P E N P A M A
Frog Xenopus laevis Q91738 1068 121137 S456 V H Q G V Y M S P E N P A M A
Zebra Danio Brachydanio rerio O13147 500 55892
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_001120873 1165 130750 G446 V H K G S Y K G R D N Q V I P
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 95.8 93.2 95.4 N.A. 93.7 96.6 N.A. 92.6 94.6 88.7 20.7 N.A. N.A. 37.5 N.A. N.A.
Protein Similarity: 100 95.8 93.8 97 N.A. 95.1 98.5 N.A. 95.3 97.6 93.9 31.6 N.A. N.A. 54.9 N.A. N.A.
P-Site Identity: 100 100 93.3 93.3 N.A. 86.6 86.6 N.A. 73.3 93.3 86.6 0 N.A. N.A. 33.3 N.A. N.A.
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 93.3 100 100 0 N.A. N.A. 53.3 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 0 82 0 82 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 10 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 82 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 91 0 0 0 10 0 0 0 0 0 0 0 % G
% His: 0 91 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 28 0 0 0 0 0 0 0 0 10 0 % I
% Lys: 0 0 10 0 0 0 10 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 0 0 0 19 0 0 0 0 0 0 55 0 % L
% Met: 0 0 0 0 0 0 55 0 0 0 0 0 0 28 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 91 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 82 0 0 82 0 0 10 % P
% Gln: 0 0 82 0 0 0 0 0 0 0 0 10 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 10 0 0 0 0 0 0 % R
% Ser: 0 0 0 0 10 0 0 73 0 0 0 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 10 10 0 0 0 0 0 0 0 % T
% Val: 91 0 0 0 55 0 0 0 0 0 0 0 10 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 91 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _